Science

The Potential Advantage of SARMs

The beneficial effects of natural androgen hormones, while minimizing the undesirable side effects

Natural steroidal hormones (testosterone, estrogens, glucocorticoids, etc.) are biologically active in their normal hormone pathways, and as such their use has often been limited by undesirable side effects. GTx designed its SARMs to produce the beneficial effects of natural androgen hormones, while minimizing the undesirable side effects.

The metabolism of natural steroids involves chemical reactions that change these molecules into other related molecules. This is one cause of the undesirable side effects that can be circumvented by treatment with GTx SARMs. Several enzymes (such as CYP19 aromatase and 5-alpha-reductase) are present in the body to convert androgen hormones to other hormones, including estrogen. Because these converted hormones control different bodily systems, it is easy to see that using androgens to target a bodily system specific to that androgen can inadvertently affect other systems.